A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables (2024)

Abstract

Objectives
To study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.

Methods
Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.

Results
Forty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.

Conclusions
There is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.

Original languageEnglish
Number of pages16
JournalJournal of Perinatal Medicine
Publication statusPublished - 2024

Keywords

  • hypoxic-ischemic encephalopathy
  • intraventricular
  • hemorrhage
  • necrotizing enterocolitis
  • neonatal heart rate
  • neonatal infection
  • seizure

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  • 10.1515_jpm-2024-0364Final published version, 3.1 MB

  • 10.1515_jpm-2024-0364Final published version, 3.1 MBLicence: CC BY

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    Eenkhoorn, C., van den Wildenberg, S., Goos, T. G., Dankelman, J., Franx, A., & Eggink, A. J. (2024). A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. Journal of Perinatal Medicine.

    Eenkhoorn, C. ; van den Wildenberg, Sarah ; Goos, T.G. et al. / A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. In: Journal of Perinatal Medicine. 2024.

    @article{dafd2601644e4a5fa7ab876ce8b13fbb,

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    abstract = "ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.",

    keywords = "hypoxic-ischemic encephalopathy, intraventricular, hemorrhage, necrotizing enterocolitis, neonatal heart rate, neonatal infection, seizure",

    author = "C. Eenkhoorn and {van den Wildenberg}, Sarah and T.G. Goos and J. Dankelman and Arie Franx and Eggink, {Alex J.}",

    year = "2024",

    language = "English",

    journal = "Journal of Perinatal Medicine",

    issn = "1619-3997",

    publisher = "Walter de Gruyter",

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    Eenkhoorn, C, van den Wildenberg, S, Goos, TG, Dankelman, J, Franx, A & Eggink, AJ 2024, 'A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables', Journal of Perinatal Medicine.

    A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. / Eenkhoorn, C.; van den Wildenberg, Sarah ; Goos, T.G. et al.
    In: Journal of Perinatal Medicine, 2024.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables

    AU - Eenkhoorn, C.

    AU - van den Wildenberg, Sarah

    AU - Goos, T.G.

    AU - Dankelman, J.

    AU - Franx, Arie

    AU - Eggink, Alex J.

    PY - 2024

    Y1 - 2024

    N2 - ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.

    AB - ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.

    KW - hypoxic-ischemic encephalopathy

    KW - intraventricular

    KW - hemorrhage

    KW - necrotizing enterocolitis

    KW - neonatal heart rate

    KW - neonatal infection

    KW - seizure

    M3 - Article

    SN - 1619-3997

    JO - Journal of Perinatal Medicine

    JF - Journal of Perinatal Medicine

    ER -

    Eenkhoorn C, van den Wildenberg S, Goos TG, Dankelman J, Franx A, Eggink AJ. A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. Journal of Perinatal Medicine. 2024.

    A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables (2024)
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