Abstract
Objectives
To study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.
Methods
Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.
Results
Forty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.
Conclusions
There is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.
Original language | English |
---|---|
Number of pages | 16 |
Journal | Journal of Perinatal Medicine |
Publication status | Published - 2024 |
Keywords
- hypoxic-ischemic encephalopathy
- intraventricular
- hemorrhage
- necrotizing enterocolitis
- neonatal heart rate
- neonatal infection
- seizure
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10.1515_jpm-2024-0364Final published version, 3.1 MBLicence: CC BY
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Eenkhoorn, C., van den Wildenberg, S., Goos, T. G., Dankelman, J., Franx, A., & Eggink, A. J. (2024). A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. Journal of Perinatal Medicine.
Eenkhoorn, C. ; van den Wildenberg, Sarah ; Goos, T.G. et al. / A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. In: Journal of Perinatal Medicine. 2024.
@article{dafd2601644e4a5fa7ab876ce8b13fbb,
title = "A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables",
abstract = "ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.",
keywords = "hypoxic-ischemic encephalopathy, intraventricular, hemorrhage, necrotizing enterocolitis, neonatal heart rate, neonatal infection, seizure",
author = "C. Eenkhoorn and {van den Wildenberg}, Sarah and T.G. Goos and J. Dankelman and Arie Franx and Eggink, {Alex J.}",
year = "2024",
language = "English",
journal = "Journal of Perinatal Medicine",
issn = "1619-3997",
publisher = "Walter de Gruyter",
}
Eenkhoorn, C, van den Wildenberg, S, Goos, TG, Dankelman, J, Franx, A & Eggink, AJ 2024, 'A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables', Journal of Perinatal Medicine.
A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. / Eenkhoorn, C.; van den Wildenberg, Sarah ; Goos, T.G. et al.
In: Journal of Perinatal Medicine, 2024.
Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables
AU - Eenkhoorn, C.
AU - van den Wildenberg, Sarah
AU - Goos, T.G.
AU - Dankelman, J.
AU - Franx, Arie
AU - Eggink, Alex J.
PY - 2024
Y1 - 2024
N2 - ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.
AB - ObjectivesTo study the methodology and results of studies assessing the relationship between fetal heart rate and specified neonatal outcomes including, heart rate, infection, necrotizing enterocolitis, intraventricular hemorrhage, hypoxic-ischemic encephalopathy, and seizure.MethodsEmbase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and CINAHL were searched from inception to October 5, 2023.ResultsForty-two studies were included, encompassing 57,232 cases that underwent fetal monitoring and were evaluated for neonatal outcome. Heterogeneity was observed in the timing and duration of fetal heart rate assessment, classification guidelines used, number of assessors, and definition and timing of neonatal outcome assessment. Nonreassuring fetal heart rate was linked to lower neonatal heart rate variability. A significant increase in abnormal fetal heart rate patterns were reported in neonates with hypoxic-ischemic encephalopathy, but the predictive ability was found to be limited. Conflicting results were reported regarding sepsis, seizure and intraventricular hemorrhage. No association was found between necrotizing enterocolitis rate and fetal heart rate.ConclusionsThere is great heterogeneity in the methodology used in studies evaluating the association between fetal heart rate and aforementioned neonatal outcomes. Hypoxic-ischemic encephalopathy was associated with increased abnormal fetal heart rate patterns, although the predictive ability was low. Further research on developing and evaluating an automated early warning system that integrates computerized cardiotocography with a perinatal health parameter database to provide objective alerts for patients at-risk is recommended.
KW - hypoxic-ischemic encephalopathy
KW - intraventricular
KW - hemorrhage
KW - necrotizing enterocolitis
KW - neonatal heart rate
KW - neonatal infection
KW - seizure
M3 - Article
SN - 1619-3997
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
ER -
Eenkhoorn C, van den Wildenberg S, Goos TG, Dankelman J, Franx A, Eggink AJ. A systematic catalog of studies on fetal heart rate pattern and neonatal outcome variables. Journal of Perinatal Medicine. 2024.